Miki and Naomi are a pair of assassins who are also friends known as Crime Mate. While Miki is pole dancing for Chinese mafia boss Ramon who deals with biological arms, Naomi warns her about an armed group of ninjas. After Miki deals with Ramon's gang and Naomi takes out the ninjas, the next day Miki sees the deceased body of Ricardo Gonzalez in her bed who offers Crime Mate a million dollars for the job. Naomi then gets kidnapped by Ramon so it is up to Miki to save her as they try to deal with Ramon. Also why is a King Cobra after them?

Some characters from Mankatsu as well as the 4 central characters from Lupin III can be seen in the background at times.

(Source: Lupin III Wiki)